LABVOLUTION Digital Edition |
Toxicity testing using organ-on-chip screening platform
A screening platform consisting of interconnectable microfluidic modules will be presented. Each module represents a tissue of the organism (e. g., intestine, liver, kidneys) and consists of a miniaturized system for the cultivation of cells. The character¬i-zation of the cells is performed with integrated optical and electrical systems. The platform includes a portable incubator microscope, which combines a microscope with a miniaturized incubator for cell culture in just one device. An integrated module for temperature control assures the cell’s temperature conditioning at 37 °C in a micro¬fluidic chip. By means of an adapted external microfluidic system, the cell culture medium is permanently renewed at very low flow rates without exposing the cells to excessive shear stress. The incubator microscope thus allows the online monitoring of the cells by bright field and fluorescence microscopy under constant cell culture conditions without using further devices. Integrated electrodes in the microfluidic chip enable the electrical characterization of the cultivated cells using impedance spectro¬scopy. The system simulates the way of toxic substances (like nanomaterials) through the human body and can be used for risk assessment of toxic substances, e. g. within the scope of REACH. Other possible applications are in pharmaceutical research and environmental analysis.
The mobile EpiLab | Mobile laboratories and medical units in use
Since 2005, the Fraunhofer Institute for Biomedical Engineering IBMT (https://www.ibmt.fraunhofer.de) ...
The »Stabil-Ice«-disposable is a novel labware in which a complete workflow can be realized from cultivation, manipulation (e. g. differentiation) to long-term storage ...