LABVOLUTION Digital Edition |
The »Stabil-Ice«-disposable is a novel labware in which a complete workflow can be realized from cultivation, manipulation (e. g. differentiation) to long-term storage through ice-free cryopreservation (vitrification) and subsequent efficient thawing processes of adherent cells. A prototype of the novel labware product will be presented in different dimensions (96-well and 24-well format) by the Fraunhofer Institute for Biomedical Engineering IBMT (https://www.ibmt.fraunhofer.de). With these disposables, standard processes in cell-based workflows for biomedical and pharma-ceutical research can be imaged and further on, a time-independent storage of adherent cell systems will be enabled. The special geometry of the disposable reduces the heat capacity of the sample and high cooling rates during the vitrification process will be achieved, so that a sterile and ice-free cryopreservation is enabled. Without the inevitable separation of phases that occurs with conventional cryopreservation, the intercellular structures and intracellular contacts of cells that usually grow adherently are preserved and can be used immediately after thawing. For system compatibility, the disposable presented is based on standard dimensions of multiwell plates and, compared to standard labware (e. g. Petri dishes), allows the complete workflow of, e. g. cell-based drug screening assays for pharmaceutical industry, in a scalable manner. Long-term storage in “ready-to-use” condition of, e. g. human stem cells and neuronal cells derived thereof, is thus made possible very easily and a game changer within the field of pharmaceutical, biotechnological and medical industries and research.
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Since 2005, the Fraunhofer Institute for Biomedical Engineering IBMT (https://www.ibmt.fraunhofer.de) ...
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