LABVOLUTION 2019, 21 - 23 May
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Liquid Biopsy - Extraction of cfDNA from Plasma

Logo truXTRAC ccfDNA

Product description

Liquid Biopsy
truXTRA cfDNA Kits
designed to standardize circulating cell-free DNA extraction;
an active AFA-based, high-throughput, high-yield system

Circulating cell-free DNA (cfDNA) are important biomarkers for non-invasive prenatal testing (NIPT), diagnosis, prognosis, and treatment monitoring of cancer, as well as diagnosis of allograft and transplant rejection.

The current methods used for the extraction and purification of cfDNA from whole blood are designed for use with fresh plasma from K3-EDTA-stabilized whole blood, requiring rapid on-site processing; leukocyte lysis and genomic DNA contamination begins shortly after collection. Alternative methods for blood collection such as the Streck Cell-Free DN BCT tubes have been specially designed for cfDNA stabilization, however, they contain fixative-releasing stabilizers that introduce complexities for the extraction step. This introduces biases in the cfDNA population when using passive extraction methodologies. Furthermore, current extraction methods involved complex workflows and were not designed for high-throughput applications.

Collectively, these barriers limit the number of samples that can practically be studied for the discovery and validation of clinically relevant mutations. The Covaris Adaptive Focused Acoustics® (AFA®) enabled truXTRAC cfDNA from Plasma kit is an active method of dissociating and extracting cfDNA from histones and other proteins, as well as apoptotic body-associated cfDNA linked complexes which occur in stabilized plasma.
Active extraction of cfDNA not only significantly increases the yield but also the complexity of the extracted cfDNA. AFA-enabled extraction ensures that the cfDNA profile in the original plasma sample is reflected in the extracted and purified sample. In addition, truXTRAC cfDNA offers a simple and efficient workflow, thereby enabling short turnaround time sample processing and high throughput implementation.

Product website

Hall 19, Stand B76

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